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Evidence Table: Neuropathy Treatments

Neuropathy treatments rated by evidence and guideline position: medicines, capsaicin, exercise, PRP and stem cells.

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Medically reviewed by Dr James Bristol, MD, PhD · Updated 2026-11-15

Medicines and foot care control symptoms day to day; stem cell and PRP treatment aim to support nerve repair, with promising clinical studies including an 8-year randomised trial in diabetes. A doctor reviews your case to recommend the right combination.

TreatmentEvidenceGuideline position
Stem cellsRecommendedPromising clinical studies, incl. an 8-year randomised trial in diabetesSpecialist regenerative option
DuloxetineStrongNICE first line; ADA first line; ASCO for CIPN
Pregabalin / gabapentinStrongNICE first line; ADA first line
AmitriptylineModerateNICE first line
Capsaicin cream / patchModerateNICE: localised pain
Glucose controlStrong (prevention)ADA
Exercise, foot careGoodRecommended
Perineural PRPOne small RCTNot in guidelines

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Last step: do you have nerve test results or a medical report?

If yes, a doctor reviews it for free and tells you whether regenerative or other non-surgical options could suit you.

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